Author

Gëorge F. Murphy

Brigham and Women's HospitalORCID 0000-0001-9362-5146Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Peter Karl SorgeriD· 4 shared Christine Guo LianiD· 3 shared Roxanne J. PelletieriD· 3 shared Tuulia ValliusiD· 3 shared Ajit J. NirmaliD· 2 shared David LiuiD· 2 shared Yevgeniy R. SemenoviD· 2 shared Yingxiao ShiiD· 2 shared

Activity by Year

2019-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersCancer Biology

Peter Karl SorgerORCID

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Author profile →

6 papers

Recent·Most cited

UV induces common cutaneous amyloid-like melanosomal protein aggregates

Nicholas Theodosakis, Porter B Howland, Miroslav Hejna, Stephen M. Ostrowski, Talya Cohen-Neamie, Remi Joseph, Helen Ji, Allison E. Greuel, Judth R. Boozer, Mariam Y. Demian, Alin Asim, Khanh Nguyen, Andrew M. Mu, Philip A. Seifert, Konrad Kaminiów, , David E. Fisher

The paper shows UV exposure causes misfolded melanosomal proteins to aggregate, contributing to skin pigmentation disorders and melanocyte dysfunction.

bioRxiv · Dec 18, 2025 · PreprintMolecular Biology

Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans

Aya Ludin, Georgia L. Stirtz, Asaf Tal, Ajit J. Nirmal, Kathleen Lindahl Pfaff, Michael P. Manos, Naomi R. Besson, Nebiyat Eskndir, Billie A. Porter, Stephanie M. Jones, Hannah Mae Faulkner, Qiyu Gong, Sophia Liu, Irving Barrera, Lijian Wu, , Leonard Ira Zon

The paper identifies crater-shaped structures in melanoma that enhance immune response to checkpoint blockade therapy in humans and zebrafish.

Cell · Oct 17, 2025Peer-reviewedCancer Biology

Multiomic profiling of a unique in-transit melanoma cohort identifies melanoma differentiation as predictor of tumor progression and therapy response

Giuseppe Tarantino, Anne Zaremba, Tuulia Vallius, Mark Woodnorth, Yichao Hua, Roxanne J. Pelletier, Mariana Lopez Leon, Yingxiao Shi, Zoltan Maliga, Samira Makhzami, Tyler J. Aprati, Bojan Karlaš, Valerie Glutsch, Bastian Schilling, Jessica C. Hassel, , Dirk Schadendorf

The paper identifies melanoma differentiation and immune exhaustion as predictors of tumor progression and therapy response in in-transit melanoma patients through multiomic profiling.

bioRxiv · Oct 1, 2025 · PreprintCancer Biology

Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma

Tuulia Vallius, Yingxiao Shi, Edward Novikov, Shishir Mani Pant, Roxanne J. Pelletier, Yu‐An Chen, Juliann B. Tefft, Ajit J. Nirmal, Zoltan Maliga, Guihong Wan, Mia DeSimone, Gëorge F. Murphy, Sandro Santagata, Yevgeniy R. Semenov, David Liu, , Peter Karl Sorger

The paper maps spatial patterns of tumor cell dedifferentiation and plasticity in melanoma by analyzing RNA and protein expression across 300 histological domains.

bioRxiv · Jun 21, 2025 · PreprintCancer Biology

PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation

Rui Fang, Tuulia Vallius, Arianna Zhang, Devon Van Cura, Francisco Alicandri, Grant M. Fischer, Elizabeth C. Draper, Shuyun Xu, Roxanne J. Pelletier, Justina Wang, Anna Mandinova, Igor Katsyv, Peter Karl Sorger, Gëorge F. Murphy, Christine Guo Lian

This study shows PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation, with reduced 5hmC levels correlating with PRAME upregulation.

Laboratory Investigation · Jul 26, 2024Peer-reviewedCancer Biology

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

Motoshi Hayano, Jae-Hyun Yang, Michael S. Bonkowski, João A. Amorim, Jaime M. Ross, Giuseppe Coppotelli, Patrick T. Griffin, Yap Ching Chew, Wei Guo, Xiaojing Yang, Daniel L. Vera, Elias Salfati, Abhirup Das, Sachin Thakur, Alice E. Kane, , David A. Sinclair

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.

bioRxiv · Oct 21, 2019 · PreprintMolecular Biology