Dual inhibition of sEH and COX-2 Improved Cognition in Alzheimer's Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility
Gilbert Charles Morgan, Andrew Gregory, Chengyun Tang, Sung Hee Hwang, Jane J. Border, Jing Xu, Yedan Liu, Shan Bai, Tae Jin Lee, Cameron Cantwell, David Bunn, Karen M Wagner, Christophe H.P. Morisseau, Carly Pittman, Alina Ngo, , Fan Fan
This study shows that dual inhibition of sEH and COX-2 with PTUPB improves cognition in AD rats by enhancing myogenic response and cerebral artery distensibility.
bioRxiv · Aug 21, 2025 · PreprintNeuroscience