Bruce D. Hammock

Inhibition of Soluble Epoxide Hydrolase Rescues Cognitive Deficits by Preserving Neurovascular Integrity and Attenuating Glial- and Neuropathology in Diabetic-Related Dementia

This study shows that inhibiting soluble epoxide hydrolase with TPPU improves cognitive function in diabetic-related dementia by enhancing cerebral blood flow and reducing neuroinflammation and gliosis.

CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION

This study identifies CES1 deficiency as a driver of metabolic reprogramming and endothelial dysfunction in pulmonary arterial hypertension, showing its role in lipid metabolism and oxidative stress.

Soluble epoxide hydrolase upregulation in Alzheimer's disease promotes blood-brain barrier dysfunction

This study shows that soluble epoxide hydrolase in astrocytes contributes to vascular instability in Alzheimer's disease, and its deletion reduces vascular amyloid burden and preserves vascular structure.

Dual inhibition of sEH and COX-2 Improved Cognition in Alzheimer's Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility

This study shows that dual inhibition of sEH and COX-2 with PTUPB improves cognition in AD rats by enhancing myogenic response and cerebral artery distensibility.

Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer's Disease and Diabetes-Related Dementia Rat Models

This study shows that inhibiting soluble epoxide hydrolase (sEH) with TPPU improves cerebral blood flow autoregulation and cognition in Alzheimer's and diabetes-related dementia rat models.

In vivo-Active Soluble Epoxide Hydrolase-targeting PROTACs with Improved Potency and Stability

This paper develops next-generation sEH-targeting PROTACs with improved potency and stability, showing effective degradation in mouse tissues.

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

This study shows that P2-HNF4 regulates ketogenesis in the liver and is involved in circadian metabolism, with implications for gender-specific ketone body levels.

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

The paper identifies EPHX1 mutations causing lipoatrophic diabetes through impaired epoxide hydrolysis and increased cellular senescence, with metreleptin therapy showing benefit.

Epoxy fatty acid dysregulation and neuroinflammation in Alzheimer's disease is resolved by a soluble epoxide hydrolase inhibitor

The paper shows that soluble epoxide hydrolase is upregulated in AD and that its inhibition restores brain epoxy fatty acids, ameliorates neuropathology, and improves cognitive function.