This study shows that inhibiting soluble epoxide hydrolase with TPPU improves cognitive function in diabetic-related dementia by enhancing cerebral blood flow and reducing neuroinflammation and gliosis.

bioRxiv · Jun 4, 2026 · PreprintNeuroscience

Dual inhibition of sEH and COX-2 Improved Cognition in Alzheimer's Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility

Gilbert Charles Morgan, Andrew Gregory, Chengyun Tang, Sung Hee Hwang, Jane J. Border, Jing Xu, Yedan Liu, Shan Bai, Tae Jin Lee, Cameron Cantwell, David Bunn, Karen M Wagner, Christophe H.P. Morisseau, Carly Pittman, Alina Ngo, , Fan Fan

This study shows that dual inhibition of sEH and COX-2 with PTUPB improves cognition in AD rats by enhancing myogenic response and cerebral artery distensibility.

bioRxiv · Aug 21, 2025 · PreprintNeuroscience

Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer's Disease and Diabetes-Related Dementia Rat Models

Chengyun Tang, Jane J. Border, Huawei Zhang, Andrew Gregory, Shan Bai, Xing Fang, Yedan Liu, Shaoxun Wang, Sung Hee Hwang, Wen‐Jun Gao, Gilbert C. Morgan, Jhania Smith, David Bunn, Cameron Cantwell, Karen M Wagner, , Fan Fan

This study shows that inhibiting soluble epoxide hydrolase (sEH) with TPPU improves cerebral blood flow autoregulation and cognition in Alzheimer's and diabetes-related dementia rat models.

GeroScience · Feb 4, 2025Peer-reviewedMolecular Biology

Epoxy fatty acid dysregulation and neuroinflammation in Alzheimer's disease is resolved by a soluble epoxide hydrolase inhibitor

Anamitra Ghosh, Michele M. Comerota, Debin Wan, Fading Chen, Nicholas E. Propson, Sung Hee Hwang, Bruce D. Hammock, Hui Zheng

The paper shows that soluble epoxide hydrolase is upregulated in AD and that its inhibition restores brain epoxy fatty acids, ameliorates neuropathology, and improves cognitive function.

bioRxiv · Jun 30, 2020 · PreprintNeuroscience