Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands
Fabrizio Fierro, Lior Peri, Harald Hübner, Alina Tabor, Lukas A. W. Waterloo, Stefan Löber, Tara Pfeiffer, Dorothée Weikert, Tamir Dingjan, Eitan Margulis, Peter Gmeiner, Masha Y. Niv
The paper discovers new ligands for the promiscuous TAS2R14 bitter taste receptor using a mixed experimental and computational approach, identifying 10 antagonists and 200 agonists.
Cellular and Molecular Life Sciences · Apr 1, 2023Peer-reviewedBioinformatics