Author

Lukas A. W. Waterloo

Friedrich-Alexander-Universität Erlangen-NürnbergORCID 0000-0002-5774-2027Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:mixed model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Dorothée WeikertiD· 2 shared Fabrizio FierroiD· 2 shared Harald HübneriD· 2 shared Lior PeriiD· 2 shared Masha Y. NiviD· 2 shared Peter GmeineriD· 2 shared Tara PfeifferiD· 2 shared Alina Tabor· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersBiochemistry

Dorothée WeikertORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedNov 18, 2024

Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14

Lior Peri, Donna Matzov, Dominic R. Huxley…·Moran Shalev-Benami

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

62 citationstop 1%

humancryo-EM

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BioinformaticsCellular and Molecular Life SciencesPeer-reviewedApr 1, 2023

Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands

Fabrizio Fierro, Lior Peri, Harald Hübner…·Masha Y. Niv

The paper discovers new ligands for the promiscuous TAS2R14 bitter taste receptor using a mixed experimental and computational approach, identifying 10 antagonists and 200 agonists.

37 citationstop 2%

humanmixed model

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