Aberrant astrocyte protein secretion contributes to altered neuronal development in diverse disorders
Alison L. M. Caldwell, Laura Sancho, James Deng, Alexandra P Bosworth, Audrey G. Miglietta, Jolene K. Diedrich, Maxim Nikolaievich Shokhirev, Nicola J. Allen
The paper identifies disorder-specific and shared changes in astrocyte protein secretion and gene expression in neurodevelopmental disorders, linking increased Igfbp2 and BMP signaling to altered neuronal development.
Nature Neuroscience · Aug 30, 2022Peer-reviewedNeuroscience