Replication stress induced by CCNE1 overexpression creates a dependency on XRCC2 at the replication fork
Kai Doberstein, Alison M. Karst, Paul Kroeger, Ronny Drapkin
The paper identifies a dependency on XRCC2 in CCNE1-overexpressing tumors, showing XRCC2's role in stabilizing replication forks and its synthetic lethality with CCNE1.
bioRxiv · May 18, 2018 · PreprintMolecular Biology