Ronny Drapkin

Expanding the therapeutic window of bacteria for cancer therapy

This paper develops a tumor-targeting engineered bacterium that improves therapeutic efficacy and safety in cancer treatment.

Structural variation in repeat elements is widespread in normal human tissues and in tumorigenesis

The paper identifies widespread mosaic structural variants in normal human tissues and tumors, with repeat-mediated variants impacting functional elements and enabling noninvasive tumor monitoring through cell-free DNA.

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinomaprecursors

This study reconstructs transcriptional trajectories of Fallopian-tube epithelium to show STICs occupy diverse positions along a progression continuum and exhibit variable PARPi resistance signatures.

Cycling Molecular Assemblies for Selective Cancer Cell Golgi Disruption

This paper develops CyMA, small peptides that disrupt cancer cell Golgi function by exploiting enzymatic cycles, showing selectivity over hepatocytes and immune cells.

Combined inhibition of NAD synthesis and C-terminal binding protein cooperatively induce cell death and inhibit growth of High Grade Serous Ovarian Carcinoma

The paper shows that combining CtBP inhibitors with NAD synthesis inhibitors enhances cell death and inhibits growth of high-grade serous ovarian carcinoma.

BRCA mutation alters the stromal landscape in normal ovaries

This study shows BRCA mutations alter ovarian stromal structure by promoting fibroblast senescence and myofibroblastic transformation, creating a metastatic niche for early ovarian cancer.

Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance

Tumor Cells Enriched for Interferon and Inflammatory Programs Pre-Exist in High Grade Serous Ovarian Cancer and are Proportionately Significantly Increased Post Chemotherapy

The paper identifies pre-existing tumor cells with interferon and inflammatory programs in HGSOC that increase after chemotherapy, suggesting a therapeutic window for intervention.

Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation

This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.

APOBEC3A drives metastasis of ovarian cancer by altering epithelial-to-mesenchymal transition

This study shows APOBEC3A promotes ovarian cancer metastasis by altering epithelial-to-mesenchymal transition in high-grade serous ovarian cancer.

ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer

This study identifies ZNFX1 as a master regulator of epigenetically-induced pathogen mimicry and inflammasome signaling in ovarian cancer, linking its expression to disease progression and survival.

Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma

This study uses spatial profiling to show immune suppression and microenvironment changes in fallopian tube precursors of high-grade serous ovarian cancer.

Performance of computational algorithms to deconvolve heterogeneous bulk tumor tissue depends on experimental factors

This study evaluates how experimental factors affect the performance of tumor deconvolution algorithms using bulk RNA-seq data.

Efficient profiling of total RNA in single cells with STORM-seq

STORM-seq improves single-cell RNA sequencing by enhancing detection of non-coding transcripts and transcript-level complexity, revealing new cell states in human fallopian tube epithelium.

Expression and function of murine WFDC2 in the respiratory tract.

This study investigates the expression and function of WFDC2 in the mouse respiratory tract, identifying its tissue distribution and functional properties.

Replication stress induced by CCNE1 overexpression creates a dependency on XRCC2 at the replication fork

The paper identifies a dependency on XRCC2 in CCNE1-overexpressing tumors, showing XRCC2's role in stabilizing replication forks and its synthetic lethality with CCNE1.

Fallopian tube precursor lesions of serous ovarian carcinoma require L1CAM for dissemination and metastasis

This study shows that L1CAM is essential for transformed fallopian tube secretory cells to detach, survive, and colonize the ovary in high-grade serous ovarian carcinoma.