Author

Kai Doberstein

Heidelberg UniversityORCID 0000-0002-9114-9913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Ronny DrapkiniD· 2 shared Alison M. Karst· 1 shared Benjamin TuschyiD· 1 shared Frederik MarméiD· 1 shared Gordon B Mills· 1 shared Kyle M Devins· 1 shared Lauren E Schwartz· 1 shared Marc SütterliniD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Ronny DrapkinORCID

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3 papers

Recent·Most cited

Interplay between BET Proteins and the Pre-Replication Complex Unveils Therapeutic Vulnerabilities in Cancer

Kai Doberstein, Vivica Messner, Sebastian Berlit, Benjamin Tuschy, Marc Sütterlin, Frederik Marmé

The paper investigates the interaction between BET proteins and the pre-replication complex in cancer cells, showing that combining BET and CDC7 inhibitors enhances therapeutic effects through DNA damage and genomic instability.

bioRxiv · Mar 27, 2025 · PreprintCancer Biology

Replication stress induced by CCNE1 overexpression creates a dependency on XRCC2 at the replication fork

Kai Doberstein, Alison M. Karst, Paul Kroeger, Ronny Drapkin

The paper identifies a dependency on XRCC2 in CCNE1-overexpressing tumors, showing XRCC2's role in stabilizing replication forks and its synthetic lethality with CCNE1.

bioRxiv · May 18, 2018 · PreprintMolecular Biology

Fallopian tube precursor lesions of serous ovarian carcinoma require L1CAM for dissemination and metastasis

Kai Doberstein, Rebecca Spivak, Yi Feng, Sarah Stuckelberger, Gordon B Mills, Kyle M Devins, Lauren E Schwartz, Marcin P Iwanicki, Mina Fogel, Peter Altevogt, Ronny Drapkin

This study shows that L1CAM is essential for transformed fallopian tube secretory cells to detach, survive, and colonize the ovary in high-grade serous ovarian carcinoma.

bioRxiv · Mar 2, 2018 · PreprintCancer Biology