Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophy
Ke’ale W. Louie, Eva H. Hasegawa, Gist H. Farr, Amanda C Ignacz, Alison Paguio, Alyssa Maenza, Alison G. Paquette, Clarissa A. Henry, Lisa Maves
The paper screens epigenetic small molecules in a zebrafish DMD model to identify SR-4370, a new HDACi that ameliorates muscle degeneration.
Molecular Therapy — Nucleic Acids · Aug 13, 2025Peer-reviewedPharmacology & Toxicology