Lisa Maves

Determining preclinical safety of Aclarubicin in pediatric malignancies

This study evaluates Aclarubicin's safety and efficacy in pediatric cancer models, finding it effective with reduced genotoxicity and cardiotoxicity compared to doxorubicin.

A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects

This study identifies proteasome factors as contributors to heart development and congenital heart defects using a systems genetics approach combining transcriptomics, PPI networks, and CRISPR screening in zebrafish.

Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophy

The paper screens epigenetic small molecules in a zebrafish DMD model to identify SR-4370, a new HDACi that ameliorates muscle degeneration.

A Machine Learning Classifier to Identify and Prioritise Genes Associated with Cardiac Development

The paper develops a machine learning classifier to identify mouse genes involved in cardiac development and prioritizes them for potential human congenital heart disease (CHD) causation.

wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome

This paper shows that wnt16 regulates spine and muscle morphogenesis in zebrafish through signals from notochord and dermomyotome, explaining its dual role in bone and muscle traits.

Evolutionarily conserved regulation of embryonic fast-twitch skeletal muscle differentiation by Pbx factors

This study shows that Pbx factors are essential for embryonic fast-twitch muscle differentiation in both zebrafish and mice, with conserved gene regulation mechanisms.

Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects

The paper tests a human PBX3 variant in zebrafish to show it may modify congenital heart defect risk by enhancing cardiac morphogenesis defects.