Alison G. Paquette

Placental microRNA signatures of spontaneous preterm birth

This study identifies microRNA signatures associated with spontaneous preterm birth and links them to target genes involved in immune signaling and oxidative phosphorylation.

The Placental Transcriptome Serves as a Mechanistic Link between Prenatal Phthalate Exposure and Placental Efficiency

This study identifies placental transcriptome genes and modules mediating the effect of prenatal phthalate exposure on placental efficiency and fetal growth.

Multi-omic integration reveals dynamic changes in human placental metabolism across gestation

The paper integrates metabolomic and transcriptomic data to identify dynamic changes in placental metabolism across trimesters in human pregnancy.

Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophy

The paper screens epigenetic small molecules in a zebrafish DMD model to identify SR-4370, a new HDACi that ameliorates muscle degeneration.

Associations Between Prenatal Vitamin D and Placental Gene Expression

This study examines the association between prenatal vitamin D levels and placental gene expression, finding 25 differentially expressed genes linked to mid-pregnancy vitamin D levels.

RNAseqCovarImpute: a multiple imputation procedure that outperforms complete case and single imputation differential expression analysis

RNAseqCovarImpute improves differential expression analysis by handling missing covariate data through multiple imputation, outperforming complete case and single imputation methods.

A Genome Scale Transcriptional Regulatory Model of the Human Placenta

The paper constructs a genome-scale transcriptional regulatory network of the human placenta using genomic and transcriptomic data, identifying key regulators of preterm birth.

Transcriptomic comparison of in vitro models of the human placenta

This study compares transcriptomes of in vitro human placental models to bulk placental tissue, finding significant gene expression differences and developing a web tool for model selection.

microRNA Expression Levels Change in Neonatal Patients During and After Exposure to Cardiopulmonary Bypass

The paper identifies miRNA expression changes in neonatal patients during and after cardiopulmonary bypass, linking them to inflammation and signal transduction pathways.

MicroRNA-transcriptome networks in whole blood and monocytes of women undergoing preterm labor

The paper identifies miRNA expression differences in whole blood and monocytes of women with spontaneous preterm labor compared to controls, linking them to immune pathways.