Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures
Jie Zheng, Winfried Maerz, Ingrid Gergei, Marcus Edi Kleber, Christiane Drechsler, Christoph Wanner, Vincent Mathias Brandenburg, Sjur Reppe, Kaare Morten Gautvik, Carolina Medina‐Gómez, Enisa Shevroja, Arthur Gilly, Young‐Chan Park, George V. Dedoussis, Eleftheria Zeggini, , Jonathan H. Tobias
This paper uses Mendelian Randomization to show that higher circulating sclerostin levels causally reduce bone mineral density and increase fracture risk.
Journal of Bone and Mineral Research · Jun 6, 2019Peer-reviewedGenetics