Denis A. Baird

The paper maps genetic associations with plasma proteins in 54,306 UK Biobank participants, identifying 10,248 new protein quantitative trait loci (pQTLs) and expanding the genetic architecture of the plasma proteome.

This study identifies six genes associated with hand grip strength using rare protein-coding variants in 340,319 individuals and shows additive effects with common variants.

The paper integrates brain RNA-seq and genotype data to identify eQTLs and their downstream effects on brain-related diseases.

PWCoCo improves genetic colocalisation by integrating conditional and colocalisation analyses, enabling robust detection of independent signals and secondary loci in high-dimensional omics data.

This study uses multi-ancestry Mendelian randomization to identify six protein targets for COVID-19 severity, showing ancestry-specific effects.

This study combines protein and gene expression QTLs to evaluate their concordance in drug target validation, finding that 25-30% of QTL pairs show discordant effects.

The paper identifies 40 novel genetic loci associated with longitudinal pediatric bone accrual and identifies candidate effector genes through variant-to-gene mapping and functional validation.

This paper uses Mendelian randomization and colocalization to identify causal relationships between plasma proteins and disease phenotypes, finding 111 putatively causal effects.

This paper uses Mendelian Randomization to show that higher circulating sclerostin levels causally reduce bone mineral density and increase fracture risk.