Sjur Reppe

The paper shows that endogenous retrotransposon activity is linked to osteocyte function and bone health, and that antiretroviral drugs may impair this activity, contributing to bone loss.

The paper identifies shared molecular mechanisms between Alzheimer's Disease and Osteoporosis using transcriptomic network analysis across brain and bone tissues.

This study uses GWAS and Mendelian randomization to show that lower sclerostin levels increase risk of hypertension, type 2 diabetes, myocardial infarction, and atherogenic lipid profiles.

This study identifies 59 genome-wide significant loci for skull bone mineral density, including four novel loci, and links them to osteoporosis and craniofacial developmental defects.

This paper uses Mendelian Randomization to show that higher circulating sclerostin levels causally reduce bone mineral density and increase fracture risk.