Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues
Nathaniel R. Kastan, Ksenia Gnedeva, Theresa Alisch, Aleksandra A. Petelski, David J. Huggins, Jeanne Chiaravalli, Alla Aharanov, Avraham Shakked, Eldad Tzahor, Aaron Nagiel, Neil Segil, Albert James Hudspeth
The paper identifies a small-molecule inhibitor of Lats kinases that promotes Yap-dependent proliferation in postmitotic mammalian tissues, enabling hair cell regeneration in the inner ear.
Nature Communications · May 25, 2021Peer-reviewedDevelopmental Biology