Eldad Tzahor

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

This paper shows that blocking glucocorticoid receptors enhances the effectiveness of growth factors in promoting cardiac regeneration by restoring MAPK/ERK signaling in cardiomyocytes.

This study identifies and characterizes circulating endothelial cells (CECs) using single-cell data, revealing their diverse origins and plasticity, and links them to angiogenic programs in cancer.

The paper identifies a cold fibrotic network in LUSC TME driven by CAFs and shows its conservation in other CIACs, suggesting therapeutic targets.

The paper models a macrophage-myofibroblast circuit to predict fibrosis types and shows targeting the myofibroblast autocrine loop reduces fibrosis after myocardial infarction.

This study identifies BMP7 as a key growth factor promoting cardiomyocyte proliferation in both mouse and zebrafish models, with potential therapeutic applications for heart regeneration.

The paper identifies a small-molecule inhibitor of Lats kinases that promotes Yap-dependent proliferation in postmitotic mammalian tissues, enabling hair cell regeneration in the inner ear.

This study identifies agrin as a critical regulator of epicardial EMT by localizing dystroglycan to the Golgi apparatus, ensuring ECM-cytoskeletal connectivity and mechanical integrity during heart development.

This study shows that ERBB2 activates YAP signaling through phosphorylation, driving EMT-like processes and cardiac regeneration in mice after injury.