Conserved catalytic activity of animal TIR domains functions in TLR4 signaling
Bohdana Hurieva, Ilya А. Osterman, Alla H. Falkovich…·Rotem Sorek
This study shows that TIR domains in animals, including human TLR4, have conserved catalytic activity that produces cADPR and is essential for TLR4 signaling.