Bohdana Hurieva

This study identifies a bacterial defense system, Metis, that detects virus-induced genome degradation through methylated mononucleotides, leading to inhibition of phage infection.

The paper identifies a bacterial defense mechanism, aRES, that depletes NAD+ by producing ADPR-1P, which resists phage NARP1 reconstitution, and describes phage countermeasures including phosphatases and inhibitors.

This study shows that TIR domains in animals, including human TLR4, have conserved catalytic activity that produces cADPR and is essential for TLR4 signaling.

The paper systematically identifies TIR-based immune signaling systems in bacteria, finding they exist in 8% of bacterial genomes and use signaling molecules similar to those in plant and human immunity.