Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and efficacy of a therapeutic anti-Abeta antibody
Marta Ramos Vega, Henrik H. Hansen, Camilla Stampe Jensen, Evdoxia Alexiou, Martin Rønn Madsen, Franziska Wichern, Jacob Lercke Skytte, Casper Graversen Salinas, Florence Sotty, Allan Jensen, Sandra B. Vergo, Jacob Hecksher‐Sørensen
This study shows that fusing an anti-Aβ antibody to a TfR1-binding Fab fragment enhances brain delivery and plaque clearance while reducing adverse effects in APP/PS1 mice.
bioRxiv · Feb 14, 2025 · PreprintNeuroscience