Author

Florence Sotty

Lundbeck (Denmark)ORCID 0000-0001-8701-3397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:electronic health records· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Aleksandra ParkaiD· 2 shared Benjamin J. HalliD· 2 shared Bettina Laursen· 2 shared Jesper F. BastlundiD· 2 shared Maiken NedergaardiD· 2 shared Paolo BottaiD· 2 shared Allan Jensen· 1 shared Camilla Stampe JenseniD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Aleksandra ParkaORCID

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Author profile →

4 papers

Recent·Most cited

Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and efficacy of a therapeutic anti-Abeta antibody

Marta Ramos Vega, Henrik H. Hansen, Camilla Stampe Jensen, Evdoxia Alexiou, Martin Rønn Madsen, Franziska Wichern, Jacob Lercke Skytte, Casper Graversen Salinas, Florence Sotty, Allan Jensen, Sandra B. Vergo, Jacob Hecksher‐Sørensen

This study shows that fusing an anti-Aβ antibody to a TfR1-binding Fab fragment enhances brain delivery and plaque clearance while reducing adverse effects in APP/PS1 mice.

bioRxiv · Feb 14, 2025 · PreprintNeuroscience

Visual evoked potentials as an early-stage biomarker in the rTg4510 tauopathy mouse model

Aleksandra Parka, Christiane Volbracht, Benjamin J. Hall, Jesper F. Bastlund, Maiken Nedergaard, Bettina Laursen, Paolo Botta, Florence Sotty

This study shows that visual evoked potentials change in early tauopathy, suggesting they could be a biomarker for early disease stages.

Journal of Alzheimer s Disease · Mar 31, 2023Peer-reviewedNeuroscience

Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model

Aleksandra Parka, Caroline Degel, Jakob Kisbye Dreyer, Ulrike Richter, Benjamin J. Hall, Jesper F. Bastlund, Bettina Laursen, Maiken Nedergaard, Florence Sotty, Paolo Botta

The paper investigates early neuronal activity impairments in the rTg4510 tauopathy mouse model, finding reduced responsivity and altered oscillatory patterns in visual cortex neurons.

Neurobiology of Disease · Jan 23, 2023Peer-reviewedNeuroscience

Long-term exposure to PFE-360 in the AAV-α-synuclein rat model: findings and implications

Michael Aagaard Andersen, Florence Sotty, Poul Henning Jensen, Lassina Badolo, Ross Jeggo, Garrick Paul Smith, Kenneth Vielsted Christensen

This study investigates the long-term effects of PFE-360 treatment in an AAV-α-synuclein rat model to assess its potential as a LRRK2 inhibitor for Parkinson's disease.

eNeuro · Nov 1, 2019Peer-reviewedNeuroscience