Tyler Kent Ulland

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

This study identifies imidazole propionate as a gut bacterial metabolite linked to Alzheimer's disease pathology through human and mouse experiments.

Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells

This paper introduces a method to enhance T cell therapy by using a CAR targeting uPAR to eliminate dysfunctional T cells through directed fratricide.

Cellular deconvolution of the brain with topological magnetic resonance image analysis

The paper introduces STRATA, a machine learning framework that estimates cell type proportions from MRI data, validated across disease models and species.

Non-invasive longitudinal imaging reveals aging-associated changes in neuroimmune cells in adult zebrafish

A 3D-printable device enables non-invasive, longitudinal imaging of adult zebrafish brains, revealing aging-associated changes in microglia dynamics.

Amyloid-beta deposition and reduced drainage at the cribriform plate lymphatics in APP/PS1 mouse model of Alzheimer's Disease

This study shows that in 24-month-old APP/PS1 mice, cribriform plate lymphatics have reduced CSF efflux and A{beta} accumulation, along with inflammation and lymphatic atrophy.

Metabolic response of microglia to amyloid deposition during Alzheimer's disease progression in a mouse model

This study uses FLIM to analyze metabolic changes in microglia of 5XFAD mice, revealing increased glycolysis and a novel fluorescence component linked to AD pathology.

Trimethylamine N-oxide reduces neurite density and plaque intensity in a murine model of Alzheimer disease

This study shows that TMAO reduces neurite density and amyloid-β plaque intensity in a mouse model of Alzheimer's disease.