Nat Murren

This paper develops a CRISPRa-based method to identify genes enhancing CAR T cell survival in different tumor environments.

This study shows that blocking the interferon-gamma axis reduces CAR T cell effectiveness against AML by impairing antigen expression and cytotoxicity, suggesting caution with IFN-gamma inhibitors in AML treatment.

This paper introduces a method to enhance T cell therapy by using a CAR targeting uPAR to eliminate dysfunctional T cells through directed fratricide.

This study measures piconewton forces transmitted by CARs during antigen engagement, showing co-stimulatory domains are essential for force generation and early signaling.