Many dissimilar protein domains switch between α-helix and β-sheet folds
Lauren L. Porter, Allen K. Kim, Swechha Rimal, Loren L. Looger, Ananya K. Majumdar, Brett D. Mensh, Mary R. Starich, Marie‐Paule Strub
The paper identifies fold-switching proteins by analyzing secondary structure propensities in the NusG family, finding 25% of sequences undergo α-helix ↔ β-sheet transitions.
Nature Communications · Jul 1, 2022Peer-reviewedBioinformatics