Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer
Daniel James Salas-Escabillas, Megan T. Hoffman, Sydney M. Brender, Jacee S. Moore, Hui‐Ju Wen, Simone Benitz, Erick T. Davis, Daniel Long, Allison M. Wombwell, Ella Rose D. Chianis, Brittany L. Allen-Petersen, Nina G. Steele, Rosalie C. Sears, Ichiro Matsumoto, Kathleen E. DelGiorno, Howard C. Crawford
The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.
Developmental Cell · Dec 24, 2024Peer-reviewedCancer Biology