Howard C. Crawford

This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.

This study shows that ferroptosis in pancreatic cancer cells induces both pro- and anti-inflammatory signals, creating an immunosuppressive tumor microenvironment in mouse models.

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

This study shows that deleting Lats1 and Lats2 in adult mouse pancreatic acinar cells causes fibrosis and inflammation through YAP1/TAZ activation.