Nina G. Steele

This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.

The paper compares primary and liver PDAC lesions using single-cell transcriptomics to identify MET as a target in pancreatic cancer metastasis.

This study identifies an opioid-mediated signaling axis in pancreatic cancer that drives extracellular matrix remodeling and tumor aggressiveness, suggesting methylnaltrexone as a potential therapeutic.

The paper identifies distinct cellular sources of Slit2/3 in the adult pancreas and shows their expression dynamics are independent of Robo2 receptor expression in islet cells.

The paper identifies four epithelial transcription states in pancreatic cancer and links their origins to early developmental processes.

SPACE improves spatial domain detection by clustering spatially variable genes while adjusting for cell type effects without requiring prior knowledge of clusters or cell types.

TESSA detects trajectory-preserved and spatially-variable genes in spatial transcriptomics, improving tumor progression analysis and spatial domain detection.

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.