Somatic variants activating the RAS-MAPK pathway confer susceptibility to hippocampal sclerosis in drug-resistant epilepsy
Lauren Mashburn‐Warren, Ashton S. Holub, Sahibjot Sran, Swetha Ramadesikan, Keaton Suh, Allison Thompson, James J. Anderson, Adithe Rivaldi, Ari Zavarella, Megan Chandler, Allison Daley, Corinne Strawser, Elizabeth A.R. Garfinkle, Jonathan Pindrik, Ammar Shaikhouni, , Tracy A. Bedrosian
The paper identifies somatic RAS-MAPK pathway activating variants in hippocampal sclerosis patients, linking them to seizure-induced injury and suggesting therapeutic targets.
bioRxiv · Apr 9, 2026 · PreprintNeuroscience