Ashton S. Holub

A cryptic START domain regulates deeply conserved transcription factors

The paper identifies and characterizes a cryptic START domain in HD-ZIPIII transcription factors, showing its role in subcellular localization, DNA binding, and ligand recognition.

Somatic variants activating the RAS-MAPK pathway confer susceptibility to hippocampal sclerosis in drug-resistant epilepsy

The paper identifies somatic RAS-MAPK pathway activating variants in hippocampal sclerosis patients, linking them to seizure-induced injury and suggesting therapeutic targets.

START domains generate paralog-specific regulons from a single network architecture

The paper identifies a mechanism by which paralogous HD-ZIPIII transcription factors generate distinct regulons through differential usage of shared binding sites, mediated by their START domains.