Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection
Laura M. Canaday, Andrew Cox, H. Alex Feldman, Harsha Seelamneni, Ayad Ali, Jasmine A. Tuazon, Lorena Botero Calderon, Sierra N Bennett, Allison Yan, Megan L Wilson, Vijayakumar Velu, Stephen N. Waggoner
This study improves NK cell transfer models in mice by showing that CRISPR-generated JAXBoy NK cells persist better than conventional BoyJ cells, and identifies roles for CXCR3 and ASCL2 in splenic NK cell localization during virus infection.
The Journal of Immunology · Jul 22, 2025Peer-reviewedImmunology