BCKDK regulates the TCA cycle through PDC to ensure embryonic development in the absence of PDK family
Lia Heinemann‐Yerushalmi, Lital Bentovim, Neta Felsenthal, Ron Carmel Vinestock, Nofar Michaeli, Sharon Krief, Alon Silberman, Marina Cohen, Shifra Ben‐Dor, Ori Jacob Brenner, Rebecca Haffner‐Krausz, Maxim Itkin, Sergey Malitsky, Ayelet Erez, Elazar Zelzer
The paper shows that BCKDK compensates for PDK family loss by inactivating PDC, maintaining TCA cycle function and embryonic development in mice.
Developmental Cell · Mar 26, 2021Peer-reviewedMolecular Biology