Elazar Zelzer

This study shows that Piezo2 in sensory neurons regulates brown and beige fat metabolism, preventing systemic hypermetabolism and improving insulin sensitivity.

This study shows that the Wnt/β-catenin pathway is essential for proprioception by coordinating the development of muscle spindle components through both cell-autonomous and non-cell-autonomous mechanisms.

The paper analyzes growth plate architecture in mouse embryos and finds that chondrocyte columns are not formed during embryonic bone elongation, suggesting different cellular mechanisms in pre- and postnatal development.

This study investigates the role of TGFβ signaling in Gli1+ cells during tendon and enthesis development, finding that it regulates proliferation, differentiation, and scleraxis expression.

This study characterizes the molecular composition of the muscle spindle using transcriptomic and proteomic data, identifies differentiation stages, and validates markers through immunostaining.

The paper uses single-cell RNA sequencing to study mouse limb development, identifying progenitor states and their differentiation into skeletal elements in a spatiotemporal pattern.

The paper identifies Gli1+ stem cells in the enthesis, shows their multipotency and therapeutic potential for tendon regeneration.

This study shows that neonatal enthesis healing occurs through non-inflammatory ECM secretion by resident cells, forming an acellular scar that restores function without inflammation or angiogenesis.

The paper shows that BCKDK compensates for PDK family loss by inactivating PDC, maintaining TCA cycle function and embryonic development in mice.

The paper identifies bi-fated tendon-to-bone attachment cells regulated by shared enhancers and KLF transcription factors, revealing how these cells integrate chondrocyte and tenocyte features.

The paper introduces 3D MAPs, a pipeline for analyzing chondrocyte morphology in growth plates, revealing allometric growth strategies and GDF5's regulatory role in tibia development.

The paper identifies global and regional genetic regulators that control the modular patterning of bone superstructures during long bone development.

The paper analyzes 3D nuclear morphology in mouse growth plates to reveal differences in nuclear shape across differentiation stages and opposing growth plates.

This study investigates the developmental mechanisms of three sesamoid bones, showing they originate from common progenitors and are regulated by different BMPs, with distinct detachment mechanisms.

The paper identifies the developmental transition of entheses from embryonic to mature states, showing that migrating entheses replace Sox9+ progenitors with Gli1 lineage cells.