Sharon Krief

Piezo2 in sensory neurons influences systemic and adipose tissue metabolism

This study shows that Piezo2 in sensory neurons regulates brown and beige fat metabolism, preventing systemic hypermetabolism and improving insulin sensitivity.

Wnt/β-catenin is required for proprioception by coordinating the multi-compartment development of muscle spindles

This study shows that the Wnt/β-catenin pathway is essential for proprioception by coordinating the development of muscle spindle components through both cell-autonomous and non-cell-autonomous mechanisms.

Molecular characterization of the intact muscle spindle using a multi-omics approach

This study characterizes the molecular composition of the muscle spindle using transcriptomic and proteomic data, identifies differentiation stages, and validates markers through immunostaining.

Neonatal enthesis healing involves non-inflammatory formation of acellular scar through ECM secretion by resident cells

This study shows that neonatal enthesis healing occurs through non-inflammatory ECM secretion by resident cells, forming an acellular scar that restores function without inflammation or angiogenesis.

BCKDK regulates the TCA cycle through PDC to ensure embryonic development in the absence of PDK family

The paper shows that BCKDK compensates for PDK family loss by inactivating PDC, maintaining TCA cycle function and embryonic development in mice.

Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

The paper identifies bi-fated tendon-to-bone attachment cells regulated by shared enhancers and KLF transcription factors, revealing how these cells integrate chondrocyte and tenocyte features.

Bone Morphology is Regulated Modularly by Global and Regional Genetic Programs

The paper identifies global and regional genetic regulators that control the modular patterning of bone superstructures during long bone development.

On the Development of Sesamoid Bones

This study investigates the developmental mechanisms of three sesamoid bones, showing they originate from common progenitors and are regulated by different BMPs, with distinct detachment mechanisms.

Development of migrating entheses involves replacement of progenitor populations

The paper identifies the developmental transition of entheses from embryonic to mature states, showing that migrating entheses replace Sox9+ progenitors with Gli1 lineage cells.