HIV-1 evasion of restriction factors: cyclophilin A and cell fusion provide a helping hand.
Henry Owen, Alun Vaughan-Jackson, Lea Nussbaum, Jane Vowles, William James, M.D. Moore
This study shows TRIMCyp restricts HIV-1 cell-free infection, while cell-cell fusion between macrophages and T cells creates 'heterocytia' that evade multiple restriction factors and AZT.
bioRxiv · Aug 2, 2018 · PreprintMicrobiology