Alun Vaughan-Jackson

This study introduces match-seq, a method to trace cell-cell interactions in vivo using CRISPR screens, revealing genetic regulators of tumor-immune interactions.

This paper introduces a synthetic cytokine receptor platform that programmably polarizes macrophages to defined functional states, showing enhanced phagocytosis and tumor reduction in mice.

The paper develops HT-recruit to measure transcriptional effector function across contexts and identifies context-dependent effectors for CRISPR-based transcription control.