Inhibitory interneurons show early dysfunction in a SOD1 mouse model of amyotrophic lateral sclerosis
Clarissa F. Cavarsan, Preston R. Steele, Landon T. Genry, Emily J. Reedich, Lynn M. McCane, Kay J. LaPre, Alyssa Puritz, Marin Manuel, Natallia Katenka, Katharina A. Quinlan
This study shows inhibitory interneurons in SOD1 mice exhibit early excitability and morphology changes, suggesting they contribute to ALS pathogenesis before motor neuron damage.
The Journal of Physiology · Dec 14, 2022Peer-reviewedNeuroscience