Marin Manuel

Whole-Mount Optical Clearing of Rabbit Tenuissimus Muscle for Assessment of Muscle Spindle Morphology

This paper describes a workflow for three-dimensional visualization of muscle spindles in rabbit tenuissimus muscle using optical clearing and fluorescent labeling.

Aberrant Pain Phenotypes Emerge Following Prenatal Hypoxic-Ischemic Injury in a Rabbit Model of Cerebral Palsy

This study shows that prenatal hypoxia-ischemia in rabbits leads to altered sensory development, allodynia, anxiety-like behavior, and changes in nociceptive afferent distribution.

A novel machine-learning classification model detects oxidative fiber type transitions in a rabbit model of cerebral palsy

This paper develops a machine-learning model to classify muscle fiber types in a rabbit model of cerebral palsy, finding oxidative fiber type shifts in affected muscles.

Chronic diazepam reveals excessive homeostatic gain in SOD1G93A mouse spinal motoneurons

This study shows that SOD1G93A mouse motoneurons exhibit exaggerated homeostatic responses to chronic diazepam inhibition compared to wild-type motoneurons.

Machine-Learning Classification of Motor Unit Types in the Adult Mouse

This study uses machine learning to classify motor unit types in adult mice based on electrophysiological properties, identifying four distinct types with high predictive accuracy.

Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration

The paper investigates how spinal microcircuits adapt in a mouse model of motoneuron degeneration, finding specific multiphasic homeostatic compensations that preserve force output.

Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy

This study shows that spinal motoneurons in a rabbit model of cerebral palsy respond abnormally to serotonin, leading to hyperexcitability and spasticity.

Inhibitory interneurons show early dysfunction in a SOD1 mouse model of amyotrophic lateral sclerosis

This study shows inhibitory interneurons in SOD1 mice exhibit early excitability and morphology changes, suggesting they contribute to ALS pathogenesis before motor neuron damage.

Conservation of locomotion-induced oculomotor activity through evolution in higher tetrapods

The paper demonstrates the conservation of locomotion-induced oculomotor activity in higher tetrapods by showing similar spino-extraocular motor coupling in mice and amphibians.

Time course of alterations in adult spinal motoneuron properties in the SOD1(G93A) mouse model of ALS

The paper shows that spinal motoneurons in ALS mice maintain excitability through homeostasis, but this process pushes some cells beyond normal conductance ranges, potentially contributing to degeneration.

Sub-optimal Discontinuous Current-Clamp switching rates lead to deceptive mouse neuronal firing

The paper shows that sub-optimal Discontinuous Current-Clamp switching rates lead to overestimation of neuronal firing in mouse spinal motoneurons.