Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation
Andreas‐David Brunner, Marvin Thielert, Catherine G. Vasilopoulou, Constantin Ammar, Fabian Coscia, Andreas Mund, Ole B. Hørning, Nicolai Bache, Amalia Apalategui, Markus Lubeck, Sabrina Richter, David S. Fischer, Oliver Raether, Melvin A. Park, Florian Meier, , Matthias Mann
The paper develops a high-sensitivity mass spectrometry workflow to quantify single-cell proteome changes upon perturbation, revealing a stable core proteome despite transcriptomic variability.
Molecular Systems Biology · Feb 28, 2022Peer-reviewedSystems Biology