Methylation dynamics in the decades preceding acute myeloid leukaemia
Adriana V.A. Fonseca, Christopher T. Boniface, Caroline J. Watson, Samuel Hackett, Calum Gabbutt, Akemi D Ramos-Yamasaki, Amanda B. Tan, Jose Montoya, Ruslan Strogantsev, L. E. Hanssen, Y Q Zhang, Sophia Apostolidou, Aleksandra Gentry‐Maharaj, Sadik Esener, Paul T. Spellman, , Jamie R. Blundell
The paper tracks DNA methylation changes in blood samples up to 15 years before AML diagnosis, identifying DMRs linked to clonal expansions and epigenetic reprogramming.
bioRxiv · Jun 26, 2025 · PreprintGenomics