In vivo lineage tracing across human tissues using methylation barcodes in the protocadherin gene cluster
Samuel Hackett, Christopher T. Boniface, Adriana V.A. Fonseca, Akemi D Ramos-Yamasaki, Caroline J. Watson, Hannah M. L.* Bazin, Amanda B. Tan, Henson L. Lee Yu, Lars L. P. Hanssen, Harveer Dev, Sophia Apostolidou, Aleksandra Gentry‐Maharaj, Sadik Esener, Usha Menon, Jamie R. Blundell
The paper uses methylation patterns in the protocadherin gene cluster to track clonal dynamics across human tissues over time, revealing subclonal architectures and cryptic expansions not detectable by standard mutation sequencing.
bioRxiv · Feb 23, 2026 · PreprintGenomics