Lars L. P. Hanssen

The paper uses methylation patterns in the protocadherin gene cluster to track clonal dynamics across human tissues over time, revealing subclonal architectures and cryptic expansions not detectable by standard mutation sequencing.

The paper tracks DNA methylation changes in blood samples up to 15 years before AML diagnosis, identifying DMRs linked to clonal expansions and epigenetic reprogramming.

The paper shows that actively transcribed genes can function as chromatin boundary elements, similar to CTCF-bound sites, by stalling chromatin loop extrusion.

CaptureCompendium provides software tools to simplify the design, analysis, and visualization of 3C experiments, addressing the need for specialized bioinformatics skills in genome folding studies.

The paper investigates promoter competition in the -globin domain using chromatin interaction data, finding that promoters interact simultaneously with a super-enhancer rather than competing.

The paper develops Tri-C, a single-cell 3C method, to reveal dynamic chromatin interactions and regulatory hubs in mammalian cells.