Antiviral signalling in human IPSC-derived neuronsrecapitulates neurodevelopmental disorder phenotypes
Katherine M. Warre-Cornish, Leo Perfect, Roland Nagy, Matthew J. Reid, Annett Mueller, Amanda Evans, Cédric Ghevaert, Grainne Mary McAlonan, Eva Loth, Declan Murphy, Deepak P. Srivastava, Jack Price
The paper shows that IFN-gamma treatment of hIPSC-derived neurons increases neurite outgrowth and alters risk gene expression, mimicking neurodevelopmental disorder features.
bioRxiv · May 10, 2020 · PreprintNeuroscience