Declan Murphy

Brain Age in Conduct Disorder: A Mega-Analysis of the ENIGMA Antisocial Behavior Working Group

This study investigates brain age differences in youth with conduct disorder compared to controls, finding accelerated brain maturation in those with adolescence-onset CD.

Linking White-Matter Development to Clinical Variation in Autism: Longitudinal Normative Modelling of FA in the EU-AIMS LEAP Cohort

This study uses longitudinal normative modelling of white matter fractional anisotropy in the EU-AIMS LEAP cohort to show individual deviations in white matter development are linked to clinical variation in autism, with significant cross-sectional and longitudinal brain-behaviour associations.

LEAP-InovAND a multiscale resource to explore genetics, brain imaging and clinical data in autism

The paper introduces a multiscale resource integrating genetics, brain imaging, and clinical data from autistic individuals and their relatives to explore genetic and neurobiological patterns in autism.

Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome

This study investigates developmental dysconnectivity in 22q11.2 deletion syndrome using a cross-species approach, finding age-specific fMRI connectivity changes with synaptic origins.

Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity derived biomarkers

This study shows that including zero-phase-delay connectivity improves the reliability and prognostic ability of functional connectivity metrics in neural populations.

Qualitative EEG abnormalities signal a shift towards inhibition-dominated brain networks. Results from the EU-AIMS LEAP studies

The paper examines EEG abnormalities in ASD and controls, finding reduced fE/I in both groups with abnormalities, suggesting inhibition-dominated networks in sensory regions.

Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis

The paper compares functional brain measures between 22qDel and CHR cohorts, finding distinct patterns of connectivity and variability disruptions.

European Autism GEnomics Registry (EAGER): Protocol for a multicentre cohort study and registry

EAGER establishes a registry of autistic individuals and those with rare genetic conditions for genomic and phenotypic research, aiming to improve clinical trials and health outcomes through data sharing.

Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits

The paper maps functional connectivity patterns in the somatosensory cortex during rest and emotional tasks in ASD and neurotypical individuals, linking them to adaptive functioning skills.

Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure

The paper investigates the relationship between glutamate and GABA gene-sets, autism symptoms, and cortical thickness using data from the EU-AIMS LEAP cohort.

Patterns of connectome variability in autism across five functional activation tasks. Findings from the LEAP project

The paper identifies patterns of neural variability in autism using fMRI across tasks, finding greater global connectivity deviations and similar spatial patterns in autistic individuals compared to controls.

Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS and sporadic congenital heart disease

The paper identifies chromatin regulatory genes as genetic modifiers of conotruncal heart defects in 22q11.2 deletion syndrome and links them to sporadic congenital heart disease.

Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort

This study identifies factors linked to early autism traits in toddlers using a community cohort, finding associations with parenting style and socio-economic deprivation.

Autism is associated with inter-individual variations of gray and white matter morphology

The paper identifies a multimodal brain pattern associated with autism by integrating gray and white matter morphology data and linking it to clinical symptoms.

Genetic correlates of phenotypic heterogeneity in autism

This study identifies genetic correlates of phenotypic heterogeneity in autism by analyzing common and de novo variants across core features and co-occurring disabilities.

Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium

The paper examines hemispheric asymmetry in structural covariance networks in ASD across 43 datasets, finding altered topological features in specific brain regions.

Differences in social brain function in autism spectrum disorder are linked to the serotonin transporter

The paper investigates serotonergic differences in ASD using fMRI and citalopram, finding a baseline group difference in 5-HTT-enriched response to facial expressions.

Towards robust and replicable sex differences in the intrinsic brain function of autism

The paper investigates sex differences in autism using resting-state fMRI data, finding significant effects in brain connectivity and replicating some findings in independent samples.

Gray matter covariations and core symptoms of autism. The EU-AIMS Longitudinal European Autism Project

The paper identifies structural covariation alterations in autism using VBM and links these patterns to core autism symptoms through canonical correlation analysis.

Atypical brain asymmetry in autism - a candidate for clinically meaningful stratification

The paper identifies atypical brain asymmetry in autism as a potential neurophenotype for stratification, showing individualized patterns linked to symptom severity and language delay.

Examining the boundary sharpness coefficient as an index of cortical microstructure and its relationship to age and sex in autism spectrum disorder

This study examines the boundary sharpness coefficient (BSC) as a measure of cortical microstructure in ASD, finding age, sex, and regional differences in BSC that correlate with clinical measures.

Attenuated Anticipation of Social and Monetary Rewards in Autism Spectrum Disorders

This study investigates reward processing in autism spectrum disorder (ASD) and finds generalized hypoactivity in the ventral striatum during anticipation of both social and monetary rewards.

Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals

This study uses iPSCs from autistic individuals to identify early neurodevelopmental differences during cortical and midbrain differentiation.

Antiviral signalling in human IPSC-derived neuronsrecapitulates neurodevelopmental disorder phenotypes

The paper shows that IFN-gamma treatment of hIPSC-derived neurons increases neurite outgrowth and alters risk gene expression, mimicking neurodevelopmental disorder features.

Differential neural circuitry behind autism subtypes with imbalanced social-communicative and restricted repetitive behavior symptoms

The paper develops a phenotypic stratification model to predict autism subtypes based on SC-RRB balance and applies it to fMRI data, identifying subtype-specific neural circuitry and gene expression patterns.

Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

This study compares intranasal and intravenous oxytocin administration effects on regional cerebral blood flow, showing systemic OT increases drive amygdala perfusion changes and validating intranasal targeting of specific brain regions.

Transcriptomic and Cellular Decoding of Regional Brain Vulnerability to Neurodevelopmental Disorders

The paper links genetic risks to spatial brain vulnerabilities in neurodevelopmental disorders using neuroimaging and gene expression data.

Altered structural brain asymmetry in autism spectrum disorder: large-scale analysis via the ENIGMA Consortium

This study identifies altered structural brain asymmetry in autism spectrum disorder using a large-scale meta-analysis of MRI data from 1,774 ASD cases and 1,809 controls.

Dissecting the heterogeneous cortical anatomy of autism spectrum disorder using normative models

This study uses normative models to analyze cortical thickness deviations in ASD, finding individualized patterns rather than common case-control differences.

Reproducible functional connectivity alterations are associated with autism spectrum disorder

This study identifies reproducible functional connectivity alterations in ASD using rs-fMRI across four large cohorts, linking them to clinical symptoms and brain regions.