Author

Leo Perfect

King's College LondonORCID 0000-0002-9014-7799Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Deepak P. SrivastavaiD· 2 shared Grainne Mary McAlonaniD· 2 shared Jack PriceiD· 2 shared Aaron R. JeffriesiD· 1 shared Akshay BhingeiD· 1 shared Alice FrankliniD· 1 shared Amanda Evans· 1 shared Annett Mueller· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Deepak P. SrivastavaORCID

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2 papers

Recent·Most cited

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.

Leonard C. Steg, Gemma L. Shireby, Jennifer L. Imm, Jonathan P. Davies, Alice Franklin, Robert J. Flynn, Seema Chandramohan Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma Walker, Leo Perfect, Jack Price, Grainne Mary McAlonan, , Eilis J. Hannon

The paper develops a novel epigenetic clock for fetal brain development to predict prenatal age in iPSCs and derived neurons, showing they remain epigenetically fetal despite differentiation.

Molecular Brain · Jun 26, 2021Peer-reviewedNeuroscience

Antiviral signalling in human IPSC-derived neuronsrecapitulates neurodevelopmental disorder phenotypes

Katherine M. Warre-Cornish, Leo Perfect, Roland Nagy, Matthew J. Reid, Annett Mueller, Amanda Evans, Cédric Ghevaert, Grainne Mary McAlonan, Eva Loth, Declan Murphy, Deepak P. Srivastava, Jack Price

The paper shows that IFN-gamma treatment of hIPSC-derived neurons increases neurite outgrowth and alters risk gene expression, mimicking neurodevelopmental disorder features.

bioRxiv · May 10, 2020 · PreprintNeuroscience