Loss of Depalmitoylation Exaggerates Synaptic Upscaling and Leads to Neuroinflammation in a Lysosomal Storage Disease
Kevin P. Koster, Edén Flores-Barrera, Emilce Artur de la Villarmois, Thu T. A. Nguyen, Amanda Niqula, Lorena Y. Noriega-González, Zach Fyke, Adriana Caballero, Stephanie M. Cologna, Kuei Yuan Tseng, Akira Yoshii
This study shows that loss of PPT1, a depalmitoylating enzyme, leads to exaggerated synaptic upscaling and neuroinflammation in a lysosomal storage disease.
bioRxiv · Dec 16, 2021 · PreprintNeuroscience