Stephanie M. Cologna

Unveiling Lipid Dysregulation: Lipidomics of Mouse Brain and Isolated Myelin in Niemann - Pick Disease Type C1

This study identifies region-specific lipid dysregulation in the cerebellum and cortex of Npc1-/- mice and myelin, revealing novel lipid alterations linked to NPC1 disease.

Immunohistochemistry-compatible gel-assisted mass spectrometry imaging

This paper introduces a method combining immunohistochemistry with gel-assisted mass spectrometry imaging to enable single-cell lipidomics in complex tissues, revealing disease-specific lipid changes in a neurodegenerative disorder.

Optimization of systemic AAV9 gene therapy in Niemann-Pick disease type C1 mice

This study evaluates the efficacy of systemic AAV9-hNPC1 gene therapy in NPC1 mouse models, finding that higher doses and earlier treatment improve survival and slow disease progression.

Multiomic Analysis Reveals Molecular Pathways Associated with Intestinal Aggregation of α-Synuclein

This study identifies dopamine production as critical for nitrite-induced α-synuclein aggregation in enteroendocrine cells, showing that benserazide inhibits aggregate formation.

Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells.

This study shows that 27HC-treated neutrophils release sEVs that induce EMT and stemness in breast cancer cells via WNT/β-catenin pathway activation.

Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimers Disease-linked pathologies in cultured human neurons

A small molecule modulates neuronal lysosome positioning and function, reducing amyloid-beta levels and rescuing pathologies in human neurons and zebrafish.

In Vivo Simvastatin and Brain Radiation in a Model of HER2+ Inflammatory Breast Cancer Brain Metastasis

This study examines if simvastatin and whole-brain radiation affect HER2+ inflammatory breast cancer brain metastases in a mouse model, finding mixed effects on micrometastases but not macrometastases.

Caveolin-1 Regulates Neurogenesis and Learning and Memory by Modulation of Mitochondrial Dynamics

This study shows that Caveolin-1 regulates neurogenesis and learning by modulating mitochondrial dynamics in neural progenitor cells.

Loss of Depalmitoylation Exaggerates Synaptic Upscaling and Leads to Neuroinflammation in a Lysosomal Storage Disease

This study shows that loss of PPT1, a depalmitoylating enzyme, leads to exaggerated synaptic upscaling and neuroinflammation in a lysosomal storage disease.