Suppression of Glucosylceramide Synthase Reverses Drug Resistance in Cancer Cells Harbor Homozygous p53 Mutants
Md Saqline Mostaq, Mohammad Nurul Amin, Amanda Raphael, Celine Asbury, Anish Ashok Gupta, Xin Gu, Xianlin Han, Davorka Sekulić, Pawel Michalak, Lin Kang, Yu Liu
This study shows that inhibiting glucosylceramide synthase (GCS) re-sensitizes drug-resistant cancer cells with homozygous p53 mutations to chemotherapy and reduces cancer stem cells.
bioRxiv · Nov 2, 2025 · PreprintCancer Biology