This study analyzes interspecies variation in the 45S rDNA locus across vertebrates, revealing lineage-specific differences in organization, copy number, and sequence evolution.

bioRxiv · Jun 29, 2026 · PreprintGenomics

The Vertebrate Genomes Project Phase I: A global reference genome resource

Giulio Formenti, Dominic E. Absolon, Linelle Ann L. Abueg, Francine Ackerman, Farooq O. Al-Ajli, Alexandre Luis Padovan Aleixo, Agostinho Antunes, Dahiana Arcila, Jean‐Nicolas Audet, Jennifer Balacco, Alan J. S. Beavan, Katherine Belov, Ricardo Betancur‐R, Shelby L. Bidwell, Matthew T. Biegler, , Fergal J. Martin

The Vertebrate Genomes Project Phase I provides high-quality reference genomes for 816 species, enabling evolutionary and conservation insights across vertebrates.

bioRxiv · Jun 26, 2026 · PreprintGenomics

Suppression of Glucosylceramide Synthase Reverses Drug Resistance in Cancer Cells Harbor Homozygous p53 Mutants

Md Saqline Mostaq, Mohammad Nurul Amin, Amanda Raphael, Celine Asbury, Anish Ashok Gupta, Xin Gu, Xianlin Han, Davorka Sekulić, Pawel Michalak, Lin Kang, Yu Liu

This study shows that inhibiting glucosylceramide synthase (GCS) re-sensitizes drug-resistant cancer cells with homozygous p53 mutations to chemotherapy and reduces cancer stem cells.

bioRxiv · Nov 2, 2025 · PreprintCancer Biology

The tuatara genome: insights into vertebrate evolutionfrom the sole survivor of an ancient reptilian order

Neil J. Gemmell, Kim Rutherford, Stefan Prost, Marc Tollis, David J. Winter, Jonathan R. Macey, David L. Adelson, Alexander Suh, Terry Bertozzi, José Horacio Grau, Chris L. Organ, Paul P. Gardner, Matthieu Muffato, Mateus Patrício, Konstantinos Billis, , Ngatiwai Trust Board

The paper presents the tuatara genome, highlighting its evolutionary significance and unique features compared to other vertebrates.

bioRxiv · Dec 8, 2019 · PreprintGenomics