Outer Pore Collapse as a Potential Mechanism of Partial Loss of Pain in Nav1.7 M899I
Vishal Sudha Bhagavath Eswaran, Estefania Torres-Ortiz, Petra A. I. Hautvast, Amdiya Botchoi, Silvia Detro‐Dassen, Anika Neureiter, Yi Liu, Ralf Hausmann, Angelika Lampert
The paper investigates the M899I variant in Nav1.7, showing it causes pore collapse, leading to loss of sodium currents and pain insensitivity.
bioRxiv · Aug 21, 2026 · PreprintBiophysics